醫聲論壇

請問， Felodipine 5mg和 Norvasc 5mg 哪一個降壓效果好?

lien897398 寫:請問， Felodipine 5mg和 Norvasc 5mg 哪一個降壓效果好?

case by case
2個都不強

我覺得ADALAT OROS 30mg 比較強
好像調降藥價後 連原廠藥藥效也變差了?! (咦)

vongreen6 寫:我覺得ADALAT OROS 30mg 比較強
好像調降藥價後 連原廠藥藥效也變差了?! (咦)

你亂講，沒變啦

我就是吃這郭的

vongreen6 寫:我覺得ADALAT OROS 30mg 比較強
好像調降藥價後 連原廠藥藥效也變差了?! (咦)

您的意思是進口廠商把國外的不良品賣到健保價超低的呆丸嗎？
(咦) (咦)

半斤八兩, 差不了多少

lien897398 寫:請問， Felodipine 5mg和 Norvasc 5mg 哪一個降壓效果好?

Felodipine 5mg !!

因病人而異,無法必較強弱 (樂奔)

CKF 寫:因病人而異,無法必較強弱 (樂奔)

正解

因該說請問， Felodipine 5mg和 Norvasc 5mg 哪一個價差好?
我來亂的

http://www.nature.com/ajh/journal/v11/n ... 8102a.html

Abstract
Amlodipine and felodipine are calcium antagonists of the dihydropyridine type. The elimination half-life of amlodipine is longer than that of felodipine.

To study whether the different elimination rates of the drugs were reflected in different duration of blood pressure (BP) control, we compared amlodipine and felodipine extended release (ER) by both conventional clinic BP 24 h after drug intake and 24 h ambulatory BP monitoring (ABPM), with special reference to nighttime and morning blood pressure.

Two hundred and sixteen patients with primary hypertension (supine diastolic BP, 95 to 115 mm Hg) were randomized to receive amlodipine or felodipine ER in a multicenter study.

The starting dose of both drugs was 5 mg.

If the target clinic diastolic BP (90 mm Hg) had not been achieved after 4 weeks the dose was increased to 10 mg. Twenty-four-hour ABPM was performed with the subjects taking placebo medication before randomization and after 4 and 8 weeks undergoing active treatment.

Significantly more patients responded after 4 weeks of treatment with amlodipine (50%) as compared with felodipine (33%) (P = .013).

ABPM during daytime (07:00 to 23:00) was similar during both treatments, but nighttime systolic (P = .026) and diastolic (P = .019) BP was more effectively reduced by amlodipine than by felodipine.

After 8 weeks 82% achieved the target pressure with amlodipine and 69% with felodipine (P = .036 for the difference).

Amlodipine seems to be more effective than felodipine when the drugs are compared in the same dose, with regard to the effect on clinic BP 24 h after dosing and to ambulatory BP during the night.

The longer elimination half-life of amlodipine as compared to felodipine is the probable reason for this finding.

MK 寫:http://www.nature.com/ajh/journal/v11/n ... 8102a.html

Abstract
Amlodipine and felodipine are calcium antagonists of the dihydropyridine type. The elimination half-life of amlodipine is longer than that of felodipine.

To study whether the different elimination rates of the drugs were reflected in different duration of blood pressure (BP) control, we compared amlodipine and felodipine extended release (ER) by both conventional clinic BP 24 h after drug intake and 24 h ambulatory BP monitoring (ABPM), with special reference to nighttime and morning blood pressure.

Two hundred and sixteen patients with primary hypertension (supine diastolic BP, 95 to 115 mm Hg) were randomized to receive amlodipine or felodipine ER in a multicenter study.

The starting dose of both drugs was 5 mg.

If the target clinic diastolic BP (90 mm Hg) had not been achieved after 4 weeks the dose was increased to 10 mg. Twenty-four-hour ABPM was performed with the subjects taking placebo medication before randomization and after 4 and 8 weeks undergoing active treatment.

Significantly more patients responded after 4 weeks of treatment with amlodipine (50%) as compared with felodipine (33%) (P = .013).

ABPM during daytime (07:00 to 23:00) was similar during both treatments, but nighttime systolic (P = .026) and diastolic (P = .019) BP was more effectively reduced by amlodipine than by felodipine.

After 8 weeks 82% achieved the target pressure with amlodipine and 69% with felodipine (P = .036 for the difference).

Amlodipine seems to be more effective than felodipine when the drugs are compared in the same dose, with regard to the effect on clinic BP 24 h after dosing and to ambulatory BP during the night.

The longer elimination half-life of amlodipine as compared to felodipine is the probable reason for this finding.

哈哈哈
好 (樂奔) 打針

lien897398 寫:請問， Felodipine 5mg和 Norvasc 5mg 哪一個降壓效果好?

健保局的看法是
哪個便宜就哪個效果好