A body-mass index between 20 and 25 seems to carry the least risk for all-cause mortality, according to a New England Journal of Medicine report that pooled data from a score of studies totaling some 1.5 million white adults.
The median follow-up was 10 years. Among initially healthy female cohort members who never smoked, the following hazard ratios for all-cause mortality were derived:
BMI Range ________________ HR
15.0 to 18.4 ............................ 1.47
18.5 to 19.9 ............................ 1.14
20.0 to 22.4 ............................ 1.00
22.5 to 24.9 ............................ 1.0 (reference)
25.0 to 29.9 ............................ 1.13
30.0 to 34.9 ............................ 1.44
35.0 to 39.9 ............................ 1.88
40.0 to 49.9 ............................ 2.51
The results among males were similar.
The authors caution that the study's generalizability is limited, given that the data are all from non-Hispanic whites.
From Journal Watch
All-Cause Mortality by Body-Mass Index
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Re: All-Cause Mortality by Body-Mass Index
Data in Asians [ from NEJM, Feb 24,2011]
'We are all just prisoners here of our own device'