英：新流感疫苗 恐致神經性疾病
【聯合報╱編譯陳世欽／報導】
2010.10.18 02:59 am
倫敦每日郵報十七日報導，英國衛生署首次承認，施打新流感疫苗可能導致人體罹患致命神經性疾病格林─巴利症候群的機率提高。專家正在深入研究兩者之間的關聯。
英國政府之前曾強調，並無任何證據足證新流感疫苗與可造成癱瘓的格林─巴利症候群有關。但英國衛生署最新公布的報告意味，英政府已改變立場。該署表示：「由於既有資訊不夠確定，我們無法排除部分民眾施打新流感疫苗後，罹患格林─巴利症候群機率微幅提高的可能性。流行病學專家正深入評估兩者間的關係。」
目前全英國已注射了六百萬劑新流感疫苗，出現十五例疑似格林─巴利症候群，病因不明，主要影響神經內層，可能導致局部癱瘓，大多影響兩手與兩腳，嚴重可能致命。
【2010/10/18 聯合報】
新流感疫苗 引發神經病變
英有15例肢體無力 衛署稱台灣僅4例 機率低
2010年10月18日蘋果日報
打新流感疫苗，國內外都曾出現格林－巴利症候群病例。 資料照片
【許佳惠、張翠蘭╱綜合報導】本月初開打的公費流感疫苗，涵括Ｈ１Ｎ１新流感病毒株，但據英國最新研究，注射新流感疫苗可能會增加併發格林—巴利症候群機會，嚴重恐致死亡。衛生署則指國內曾接獲四例注射新流感疫苗後，出現格林—巴利症候通報案，僅一例因無法排除，略予補助，因此症候群發生機會低，仍建議施打疫苗。
國外研究
英國《每日郵報》報導，英國藥物保健產品管理局首度證實，接種新流感疫苗會些微增加罹患格林—巴利症候群風險，並已接獲十五起疑似病例。英國婦人威金森接種新流感疫苗後，出現格林—巴利症候群包括多發性神經病變與胸部感染，治療後才恢復行走與說話能力。她說：「這真是嚇人的病症，新流感疫苗副作用應多加研究。」
對此，衛生署疾病管制局發言人施文儀昨指在一般沒接種疫苗情況下，國內每周都會有幾例格林—巴利症候群病例，接種流感疫苗期間，通報個案也沒明顯增多，國人仍應打疫苗。
據疾管局資料，國內去年秋冬至今年三月十六日新流感疫苗接種期間，從約五百六十六萬名接種者中，僅發現四例格林—巴利症候群，而今年十月開打的流感疫苗，則尚未接獲通報。感染症醫學會發言人、台大醫院醫師李秉穎指上述四人，後經衛生署所聘專家審議，僅一例因無法排除與疫苗相關，從寬略予補助，其他三例均排除。
避免流感 仍應施打
李秉穎說，格林—巴利症候群患者可能肢體無力，嚴重者會癱瘓、死亡，而由疫苗引發的格林—巴利症候群，通常在接種六周後發生，任何疫苗都可能引發，感染與自體免疫問題，也可能引發此症。他強調，不管新流感疫苗或今年流感與新流感混合的疫苗，發生格林—巴利症候群機率都低於百萬分之一，仍會建議民眾接種，以免流感上身。
疫苗施打 注意事項
●正發燒、身體抵抗力較差時，皆不適合接種疫苗
●對雞蛋過敏者不宜施打流感疫苗
●施打疫苗後若有雙側肢體無力等症狀，應盡快就醫檢查神經傳導功能
●任何疫苗，尤其是流感疫苗、新流感疫苗，可能引起格林─巴利症候群，但機率低於百萬分之一
●接種疫苗後應留下觀察30分鐘，無不適再離開
資料來源：李秉穎醫師、《蘋果》資料室
Experts admit swine flu jab 'may cause' deadly nerve disease
By Jo Macfarlane
Last updated at 11:24 PM on 16th October 2010
Health chiefs have for the first time acknowledged that the swine flu jab may be linked to an increased risk of developing a deadly nerve condition.
Experts are examining a possible association between the controversial jab and Guillain-Barre Syndrome, according to a report from official watchdog the Medicines and Healthcare products Regulatory Agency (MHRA).
Previously, the Government has always stressed there is no evidence to link the paralysing condition to the H1N1 vaccine.
After The Mail on Sunday revealed in August 2009 that doctors were being asked to monitor cases of GBS during the swine flu pandemic, a letter from the Health Protection Agency’s chief executive Justin McCracken stated: ‘There is no evidence to suggest an increased risk of GBS from the vaccines being developed to fight the current pandemic.’
Now the MHRA’s newly published report suggests the Government’s position has changed.
It says: ‘Given the uncertainties in the available information and as with seasonal flu vaccines, a slightly elevated risk of GBS following H1N1 vaccines cannot be ruled out. Epidemiological studies are ongoing to further assess this possible association.’
It is not known precisely what causes GBS but the condition attacks the lining of the nerves, leaving them unable to transmit signals to muscles effectively.
It can cause partial paralysis and mostly affects the hands and feet – but it can be fatal.
The MoS report last year
The MoS report last year
Mother-of-two Hilary Wilkinson, 58, from Maryport, Cumbria, developed GBS following a chest infection and spent three months in hospital learning to walk and talk again.
She said: ‘It’s a frightening illness and I think more research needs to be done on the effect of the swine flu vaccine.’
A vaccine used to combat a different form of swine flu in the US in 1976 led to 25 deaths from the condition, compared with just one death from swine flu itself.
Amid fears there could be a repeat, neurologists were asked to record cases of GBS in the UK swine flu outbreak. Millions of people this year will be exposed to the swine flu vaccine as it has been included within the seasonal flu jab.
Government experts say there is no evidence of an increase in risk similar to 1976, but the MHRA report reveals they are calculating if there might be a smaller raised risk.
The MHRA had 15 suspected GBS cases after vaccination – and six million doses of the swine flu jab Pandemrix were given. It is not known if swine flu or the vaccine could have caused the suspected cases.
A spokeswoman for the MHRA said the risk with the vaccine had not changed and that the report ‘simply expands’ on ongoing GBS analysis.
英：新流感疫苗 恐致神經性疾病
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