請問大家Statin起始後，多久檢驗一次肝指數？

[philip chen]

Statin起始後，4-6週驗GOT GPT?
之後沒6-12月驗一次？

Statin 的肝毒性，是dose-dependent? 或是使用時間長短？和水溶性、脂溶性有關？比較強的Rosuva Atorva 會比較產生肝毒性？

以上請教！


以下是爬文結果！
LFT should be carried out before and within 4-6 weeks of starting statin therapy (1). Thereafter at intervals of 6 months to 1 year - earlier if clinical features of hepatotoxicity; also at the first review at 4-6 weeks - enquire about adverse effects such as itching, rash, myalgia, arthralgia, insomnia (1)
if satisfactory lipid control and no evidence of adverse effects then review again at 4-6 months, then 6-12 monthly
if unsatisfactory lipid control then measurements should be repeated 6 weeks after dosage adjustments are made until the desired lipid concentrations are achieved (2)
however NICE state that LFTs only need to be measured on three occasions:
baseline liver enzymes should be measured before starting a statin. Liver function (transaminases) should be measured within 3 months of starting treatment and at 12 months, but not again unless clinically indicated
people who have liver enzymes (transaminases) that are raised but are less than 3 times the upper limit of normal should not be routinely excluded from statin therapy
treatment should be discontinued if serum transaminase concentrations rise to, and persist at, 3x normal range

[monger]

我驗了
也被扣了
也去申付，爭議都沒回來

[amin30]

審查要刪，就跟天要下雨，娘要嫁人一般無奈

[Felix]

我驗了
也被扣了
也去申付，爭議都沒回來

http://www.nhi.gov.tw/resource/bulletin ... %AE%9A.pdf

給一般老百姓看的文件:其中的處方規定,明白寫著"請注意副作用之產生如肝功能異常"
說得多好聽呀~~背後卻砍你一刀
再次證明G8G:善用兩面手法,習慣說假話

[a7662888]

FDA 已經改Label了
可以附上去看看申覆會不會過
http://www.fda.gov/drugs/drugsafety/ucm293101.htm

Monitoring Liver Enzymes

Labels have been revised to remove the need for routine periodic monitoring of liver enzymes in patients taking statins.